What is the scientific basis for Prolotherapy?

Prolotherapy is an established technique for healing lax, stretched, or torn joint ligaments and muscle tendons. The technique consists of injecting a proliferant solution at the site of attachment of the ligament or tendon to the joint bone.

The proliferant solution consists of a combination of Procaine™ (local anesthetic) and glucose. Platelet-rich plasma (PRP) is a variation of the standard proliferant solution. The proliferant solution stimulates the formation of an inflammatory reaction at the site of the ligament or tendon sprain injury. That inflammation attracts the presence of growth factors, which stimulate the proliferation of the cells of the ligament or tendon. PRP consists of a platelets, which contain those same growth factors. The stimulated ligament or tendon cells generate and lay down new ligament or tendon collagen tissue. The proliferation of new collagen heals the ligament or tendon sprain injury.