What are the risks or complications of Prolotherapy?

The potential risks or complications of Prolotherapy are the same as for any medical injection therapy (e.g., flu shot, penicillin shot, cortisone shot):
  • No effect from the treatment
  • Immediate pain at the injection site, lasting 100 hours (3-4 days) or more
  • Bruising of the general treatment area
  • Bleeding at the injection site
  • Fainting or dizziness
  • Post-therapeutic tendinosis pain flare
  • Post-therapeutic muscle spasm
  • Similar to risk of surgical intervention, temporary (transient) or permanent injury to cutaneous nerves or muscles at the injection site
  • Autonomic nervous system-related skin and sensory changes
  • Sensory numbness or pain, aching, or burning sensations, or
  • Motor paralysis
  • Spinal cord injury during back injections
  • Pneumothorax (air on the outside of the lung) during chest injections
  • Allergic reaction to one of the components of the proliferant solution. This may be in the form of mild skin reactions or severe anaphylactic shock. Consequently, a careful allergic history needs to be taken and if there is any question, skin testing is advisable and available.
  • Death from allergic complications of the treatment.

Is anticoagulation therapy a contraindication to receiving Prolotherapy?
Any patient who is taking any anticoagulation therapy, e.g., heparin, Coumadin (Warfarin), Plavix (Clopidogrel), is not a Prolotherapy candidate. Note: 80 mg of Aspirin a day is acceptable.